The Effect of Structural Characteristics of Deproteinized Spongy Bone on Activity of Adipose Tissue Mesenchymal Stromal Cells.

We studied the effect of structural properties of deproteinized spongy bone (DSB) on functional activity of adipose tissue mesenchymal stromal cells of (MSC) for the potential use of these materials as components of a combined tissue-engineered construct. The porosity of the structure of DSB samples and the pore size promote MSC adhesion, migration, and proliferation on their surface and in the depth, revealing the architectonics of this bone matrix. The depth of cell penetration into the samples (from 273 to 702 µm) and an increase in the total number of cells (from 302 on day 1 to 1744 on day 7) demonstrated MSC adhesion, migration, and proliferation. The viability of cultured MSC was preserved for up to 7 days. The obtained results prove the possibility of using allogeneic DSB from femoral heads as a bone matrix in tissue-engineered constructs in combination with MSC. Such constructs can be used to efficiently restore the structural and functional integrity of the bone tissue in abnormal processes of various etiopathogenesis associated with the formation of bone defects or bone tissue deficiency.

[Rehabilitation of patients after surgical treatment of avulsion rupture of the distal biceps brachial tendon]. / Reabilitatsiya patsienta posle khirurgicheskogo lecheniya avul'sionnogo razryva distal'nogo sukhozhiliya dvuglavoi myshtsy plecha.

Avulsion subcutaneous rupture of the distal tendon of the biceps brachial is a relatively rare occurrence. In the context of postoperative treatment, there are isolated references to rehabilitation therapists and sports physicians in the literature. However, the popularization of sports among the general population forces specialists to face this problem in clinical practice. The objective of the presented study was to review our own concept of rehabilitation in the early and late postoperative periods using the example of a specific clinical case of surgical treatment using fixation with a cortical button and an interference screw in trauma in a professional athlete. A group of surgeons and rehabilitation therapists focused their efforts on returning the patient to normal amplitudes of movements in the joints of the injured limb the ability to endure previous loads without pain in the shortest possible time without fear of relapse. The results obtained during the treatment of a sports-organized patient with an avulsion rupture of the distal tendon of the biceps brachial made it possible to question the success of the previous «immobilization¼ concepts broadened the professional understanding of the possibilities of modern rehabilitation allowed surgeons and rehabilitation therapists to come close to developing a universal rehabilitation protocol form.